Bypassing the bottleneck: intentional hepatitis C transmission with organ transplant

HEPATOLOGY EZsewhere HEPATITIS C VIRUS TRANSMISSION DURING ORGAN TRANSPLANTATION

Background. There is a high prevalence of liver disease among the recipients of organs from donors with antibodies to hepatitis C virus (HCV). We undertook a study to determine the frequency of persistent HCV infection, as indicated by the presence of HCV RNA, among both cadaveric organ donors positive for antibodies to HCV (anti-HCV) and the recipients of organs from these donors. Methods. Ser...

Hepatitis C virus infection and risk of post-transplant lymphoproliferative disorder among solid organ transplant recipients

Viral hepatitis in solid organ transplant recipients.

Hepatotropic viral infections are frequent in allograft recipients and may be caused by a number of different viruses. Of these, the most important infectious agents are hepatitis B virus (HBV) and hepatitis C virus (HCV), which can cause both acute and chronic hepatitis. In addition, Hepatitis E virus (HEV), thought previously to only cause acute hepatitis in the developing world, is emerging ...

Bypassing Knowledge Acquisition Bottleneck with Bayesian Word Sense Induction

We use Bayesian topic modeling techniques adapted to the task of unsupervised word sense induction on acronyms in clinical text and investigate (1) the amount of annotated data needed by such approaches to match the performance of the supervised sense disambiguation systems, and (2) feasibility of using an automatically collected silver standard for such techniques. A dataset of ambiguous abbre...

Discordant hepatitis C serological testing in Australia and the implications for organ transplant programs.

BACKGROUND Discordant and equivocal hepatitis C (HCV) serology testing is problematic for making decisions regarding deceased organ donor (DOD) transplant allocation based on allograft infection status. OBJECTIVES This study aimed to analyse the prevalence and follow-up testing of discordant HCV tested patients from an Australian population at increased risk of HCV infection, with prevalence ...